Danielle Picarello

At Icahn School of Medicine at Mount Sinai, I lead the genomic and multi-omic center for DIAN, integrating WES, WGS, and genotype array data. I maintain reproducible Snakemake pipelines for sequencing QC and analysis, and curate genetic datasets that support consortium projects and publications. I apply GWAS, MAGMA gene-level analysis, and pathway enrichment to identify candidate risk genes and pathways in Alzheimer’s disease and Lewy body dementia. I’m drafting a first-author manuscript on this work. Earlier, at Lehigh University, I implemented CHARMM GUI simulations of bacterial membrane systems and analyzed membrane properties. As a Rosetta Commons Intern, I contributed a weighted hydrophobicity attribute to Rosetta’s scoring algorithm to improve protein structure predictions.